منابع مشابه
Toxicity of methyldopa (Aldomet) to mouse neuroblastoma cells in vivo.
The adrenergic blocking agent methyldopa (Aldomet) is toxic to C-1300 neuroblastoma cells in vivo. Four injections of Aldomet at a dose of 7.5 mg/injection were given over a period of 24 hr to C-1300 neuroblastoma-bearing mice. This treatment killed a significant proportion of the C-1300 neuroblastoma cells. Flow cytometric data suggest that sensitivity of tumor cells to Aldomet is not related ...
متن کاملA Comparison of Dexmedetomidine, Moxonidine and Alpha-Methyldopa Effects on Acute, Lethal Cocaine Toxicity
BACKGROUND The treatment of cocaine toxicity is an important subject for emergency physicians. We investigated the effects of dexmedetomidine, moxonidine and alpha-methyldopa on acute cocaine toxicity in mice. OBJECTIVES The aim of this study was to evaluate the effects of dexmedetomidine, moxonidine and alpha-methyldopa in a mouse model of acute cocaine toxicity. MATERIALS AND METHODS We p...
متن کاملCholestatic jaundice due to methyldopa.
The occurrence of hepatitis in patients taking methyldopa was first described over 10 years ago (Gillespie et al., 1962). Though the degree of bile retention in puiblished case reports varies considerably (Tysell and Knauer, 1971) the clinical picture described is generally indistinguishable from viral hepatitis. When the following patient was seen drug-induced jaundice was suspected but as we ...
متن کاملAntihypertensive Metabolites of a-Methyldopa
a-Methyldopa acts through a metabolite in the central nervous system. Of the three metabolites most prominently considered as potential mediators of a-methyldopa hypotension — amethyldopamine, a-methylnorepinephrine (MNE), and a-methylepinephrine (ME) — ME is the most potent depressor agent following intravenous infusion into rats, following injection into the lateral ventricle, and following i...
متن کاملa comparison of dexmedetomidine, moxonidine and alpha-methyldopa effects on acute, lethal cocaine toxicity
conclusions the present study provides the first experimental evidence in support of dexmedetomidine treatment for cocaine-induced seizures. premedication with dexmedetomidine reduces seizure activity in a mouse model of acute cocaine toxicity. in addition, while dexmedetomidine may be effective, moxonidine and alpha-methyldopa did not effectively prevent cocaine-induced lethality. results the ...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1976
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(76)80433-7